FRI0577 VITAMIN D LEVEL IN HEALTHY CANARIAN ADULT POPULATION

Background: Vitamin D (VitD) was first used to treat rickets in children in depressed urban areas of England, due to malnutrition and lower sun exposure. During the last decade its use has become widespread in western societies because it has been associated with lower risk of suffering from multiple diseases and there is also a lack of consensus in establishing adequate levels for the general population. Regarding the beneficial effects of VitD, well-designed current observational studies are calling them into question and many authors believe that levels of 30 ng/mL, adopted as optimal, are overestimated1-2. All this has led many individuals who come to our consultations to use supplements without scientific evidence of their benefits. Objectives: The main objective was to determine the distribution of VitD levels in the healthy canarian population, an area with high solar radiation and stratified according to demographic factors (age, sex and place of residence). As a secondary objective, the study was established to determine prevalence of hyperparathyroidism hypercalcemic in the canarian population. Methods: Cross-sectional population study to determine VitD levels in healthy subjects. The EPIRCAN study screen was used, a population study carried out between 2004 and 2005 to determine the prevalence of rheumatic diseases in the Canary Islands. In 949 serums, the levels of VitD, phosphorus and calcium were determined, as well as Parathyroid hormone (PTH), only in which calcium levels were >10,4 mg/dl. Data were analysed according to demographic characteristics, comorbidities and medication. For the statistical analysis the SPSS was used. Results: The sociodemographic characteristics (age, sex and rural/urban population) of the 949 samples were representative of the Canarian population in the period studied according to data of the ISTAC (Canary Institute of Statistics) with a level of accuracy of 0.7 ng/ml for the vitD and a confidence level of 95%. Healthy (n=876, 92.3%) and sick subjects (n= 73, 7.7%) (renal failure, dialysis, Crohn’s, ulcerative colitis, osteoporosis, calcium supplements, vitD, bisphosphonates or calcitonin). The median and Interquartile range of vitD levels in the entire population studied was 26.3 (20.9-32.9) ng/ml. The VitD levels distribution of healthy population was: 66% were below 30 ng/ml,23% were below 20 mg/ml and 4% were below 12,5 ng/ml. According to the age groups, sex and location: women versus men have 2.8 ng/ml less VitD (CI95%: 1.487;4.177). As the age increases the VitD values decrease; those aged 20-45 with respect to ≥65 years have 5.5 ng/ml more (CI95%: 3.574;7.592), those 45-65 years old have 2.397 ng/ml more (CI95% 0.255;4.539) with respect to ≥65 years, being statistically significant. There were no significant differences between the rural and urban population. The prevalence of hyperparathyroidism hypercalcemic was 0.2%. Conclusion: In the healthy population, baseline levels of VitD are higher in men than in women and tend to decrease with age. Due to the distribution of VitD levels in a healthy population, in an area of high sun exposure, seems to be more reasonable to establish the optimal VitD levels in the general population at 20 ng/ml instead of the established 30 mg/ml. References: [1] F. Wu et al. Cut-points for associations between vitamin D status and multiple musculoskeletal outcomes in middle-aged women. (2017). Osteoporosis International; Volume 28, Issue 2, pp 505–515. [2] E. Manson, J. (2016). Vitamin D Deficiency — Is There Really a Pandemic? The New England Journal of Medicine, pp.75;19. Disclosure of Interests: None declared