pH sensitive nanoparticles prodrug with capacity of co-delivering multiple drugs, preparation method and application thereof

The invention relates to a pH sensitive nanoparticles prodrug with capacity of co-delivering multiple drugs, a preparation method and an application thereof. According to the invention, an external layer is polyethylene glycol possessing highly biological compatibility, a core is hydrophilic terminal bond and an antitumor drug doxorubicin (DOX), and the other hydrophobic antitumor drug curcumin (Cur) is coated through a hydrophobic effect. A structure is PEG-DOX-W-NPs. Under pH response condition, the nanoparticles prodrug can simultaneously release multiple antitumor drugs through disintegration for performing combination therapy effect. The provided pH sensitive nanoparticles prodrug has the advantages of good biology compatibility and long internal effect time. The preparation method has the advantages of simple process, good stability, and convenient operation and popularization.