The function of E3B1 in tumors and its mechanisms

E3B1, an EPS8 binding protein, has a variety of biologic functions. It is involved in cytoskeleton remodeling, GFR-mediated cellular response and cell growth inhibition. In the form of E3B1-EPS8-SOS1 complex, E3B1 also plays an important role in Ras to Rac cell signaling. These functions endow E3B1 and its familial proteins with a potential role for inhibiting tumor, and make them closely related to tumorigenesis and tumor development. Presently, studies on E3B1 are mainly focused on its signaling pathway. Further researches on E3B1 will be concentrated on its function and mechanisms in pathogenesis of tumor, which may provide some critical theoretical clues for studies on tumor metabasis and transformation.