The H+/K+ ATPase Inhibitor SCH-28080 Inhibits Insulin Secretion and Induces Cell Death in INS-1E Rat Insulinoma Cells

Martin Jakab,Nina Ketterl,Johannes Fürst,Marlena Beyreis,Michael Kittl,Tobias Kiesslich,Cornelia Hauser-Kronberger,Martin Gaisberger,Markus Ritter

The H+/K+ ATPase Inhibitor SCH-28080 Inhibits Insulin Secretion and Induces Cell Death in INS-1E Rat Insulinoma Cells

2017

Martin Jakab
Nina Ketterl
Johannes Fürst
Marlena Beyreis
Michael Kittl
Tobias Kiesslich
Cornelia Hauser-Kronberger
Martin Gaisberger
Markus Ritter

Background/Aims: Glucose-stimulated insulin secretion (GSIS) of pancreatic β-cells involves glucose uptake and metabolism, closure of KATP channels and

Keywords:

Biochemistry
Diabetes mellitus
Rat Insulinoma
Insulin
Biology
Glucose uptake
Secretion
Internal medicine
Apoptosis
Endocrinology
ATPase
Programmed cell death
Patch clamp
Viability assay
Propidium iodide
Hyperpolarization (biology)
Exocytosis
Intracellular pH

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