Long-lasting Changes of Albino Rats Behavior and Brain Bioamines Content After Immunization Against Cholecystokinin-3 and -4

Active immunization against cholecystokinin fragments 31–33 (CCK-3) and 30–33 (CCK-4) results in long-lasting changes of albino rats’ behavior. CCK-3 and CCK-4 covalently linked to antigen-carrier evokes the suppression of the anxiety, decreases some signs of depression-like behavior and changes the level of bioamines and their catabolites in striatum at least for two months after immunization. These data can provide a perspective approach to the problem of long term correction of behavior.