Gentamicin trough levels using a simplified extended-interval dosing regimen in preterm and term newborns

To evaluate a simplified gentamicin extended-interval dosing regimen in a large cohort of preterm and term newborns, we conducted a retrospective cohort study over a 4-year period. All inborn newborns who received gentamicin for the first episode of suspected or proven sepsis were eligible. Newborns received 4 mg/kg gentamicin intravenously 24-hourly, except for those at 2 μg/mL was between 2.2 and 9.7 % in all subgroups except for infants born at 28–31 weeks of gestation, where 21.7 % of trough levels were >2 μg/mL. Indomethacin co-medication significantly increased the median gentamicin trough level in preterm infants at <32 weeks of gestation.