The therapeutic value of endoscopic nasobiliary drainage for the infection of biliary tract associated with endoscopic retrograde cholangiography

Objective To explore major risk factors for postoperative biliary tract infection associated with endoscopic retrograde cholangiography (ERC), and to evaluate endoscopic nasobiliary drainage (ENBD) for intervening the infection. Methods A total of 512 patients who underwent ERC at the First People′s Hospital of Yunnan Province from January 2010 to June 2016 were enrolled and divided into group A and B randomly. Group A underwent ENBD after ERC while group B without. The incidence rates of biliary tract infection in different causes and lesions were compared between the two groups. Results Among the 512 patients, there were 276 cases in group A and 236 cases in group B. The overall postoperative biliary infection rate was 4.30%(22/512). Patients in group A showed a smaller chance of developing postoperative biliary tract infection than that in group B [1.09%(3/276) VS 8.05%(19/236), χ2=15.00, P=0.000]. Malignant biliary obstruction was the most common cause (13.46%, 14/104) and the most common site was hepatic portal (13.43%, 9/67). Conclusion ENBD can ensure smooth drainage of bile duct therefore effectively prevent biliary tract infection after ERC, especially for patients with malignant biliary obstruction and hepatic portal lesion. Key words: Infection of biliary tract; Cholangiography, endoscopic retrograde; Endoscopic nasobiliary drainage