Cu Core Shell Nanosphere Based Electrochemical Non-Enzymatic Sensing of Glucose

Abstract In this study, we prepared Copper (Cu) metal-based core shell nanosphere (spherical Cu/CuO/SiO2 nanostructures with approximately 100 nm size) using a green ultrasound method for investigation the electrochemical sensing of glucose, fructose, lactose, and maltose. In the non-enzymatic glucose Cu-core shell nanosphere sensor based on electrode surfaces, we proved that the morphology of the electrode material has a large impact on the performance of the sensor. The Cu core shell nanospheres were prepared by using nontoxic, biodegradable, and biocompatible biopolymer chitosan, which were modified by an inorganic phase SiO2. Electrochemical properties of Cu core shell nanospheres were compared against glucose, fructose, lactose, and maltose in PBS. The electrochemical measurement results indicate that prepared Cu core shell nanosphere based electrochemical sensor has a higher sensitivity and selectivity against to glucose. Prepared Cu core shell nanosphere based electrochemical sensor detected [3-12] mM glucose with sensitivity of 8 μA. mM−1. cm-2 during 1 min cyclic voltammetry measurement. Lower limit of detection of the prepared glucose sensor was found to be 1.45 mM. This study reveals new high potential novel Cu core shell nanosphere based sensing material for selective detection of glucose with high sensitivity. The innovation of non-enzymatic glucose sensors with synthesized Cu core shell nanosphere in this study was proposed and was shown from a promising perspective in this period.