559PPROGNOSTIC IMPACT OF GWAS-IDENTIFIED GENETIC VARIATIONS IN PATIENTS WITH COLORECTAL CANCER

ABSTRACT Aim: Genome-wide association studies (GWAS) have identified at least 22 single nucleotide polymorphisms that are associated with the risk of colorectal cancer. We examined the relationship between these single-nucleotide polymorphisms (SNPs) and clinical outcomes of patients with colorectal cancer. Methods: 772 patients with surgically resected colorectal adenocarcinoma were enrolled in the present study. 22 GWAS-identified SNPs were genotyped using a Sequenom MassARRAY. Results: Among the 22 SNPs, two SNPs (rs1321311G > T in CDKN1A and rs10411210C > T in RHPN2) were significantly associated with survival outcomes of CRC in multivariate survival analysis. In recessive model, rs1321311TT (vs. GG + GT) and rs10411210 TT genotype (vs. CC + CT) exhibited worse prognosis in disease-free survival (DFS) (adjusted HR = 2.05; 95% confidence interval = 1.11-3.78; p = 0.0022, adjusted HR =1.93; 95% confidence interval = 1.04-3.57; p = 0.037, respectively) and overall survival (OS) (adjusted HR = 2.20; 95% confidence interval = 1.12-43, p = 0.0023; adjusted HR =2.20; 95% confidence interval 1.01-3.95; p = 0.047, respectively). Other SNPs were not associated significantly with clinicopathologic features or survival. Conclusions: The present results suggest that genetic variants of the CDKN1A (rs132111) and RHPN2 (rs10411210) genes could be used as prognostic biomarkers for patients with surgically resected colorectal cancer. Disclosure: All authors have declared no conflicts of interest.