Subacute sclerosing panencephalitis-a case report.

416 Subacute sclerosing panencephalitis (SSPE) is a rare disease caused by defective measles vaccination or virus in children [1] . The typical neurologic manifestations of this disease include subtle changes in mental status at initial presentation, followed by myoclonus, motor incoordination, visual defect, and speech impairment. The disease then progresses to stupor, coma, and death [2,3]. The average clinical course is 1 to 3 years with rare spontaneous remissions [4,5]. Numerous therapeutic agents have been reported to be beneficial in the treatment of SSPE [6]. However, recent reports have suggested that combination treatment with inosiplex and interferon-α (IFN-α) may be most effective in slowing the progression of SSPE [7–9]. We report a case of SSPE with typical histopathologic findings on brain biopsy [10], who received intraventricular IFN-α and oral inosiplex combination treatment [7]. We also discuss the clinical response.