Agreement Between Automated and Clinically-Reported Manual ROIBased MR Elastography Liver Stiffness Measurements in Children and Young Adults.

MR elastography (MRE) typically requires manual ROI placement to generate liver shear stiffness measurements. Among 419 patients (primarily children and young adults), a computer-based automated MRE processing tool and clinically-reported manual ROI-based measurements generated similar results (mean bias=0.13 kPa). Intra-class correlation coefficient was 0.94 and at least 0.90 across common indications, in males and females, and in patients with and without elevated liver fat fraction. Automated analysis may promote post-processing standardization and decrease reporting variability.