Spontaneous disappearance of focal ground-glass opacity in the lung detected on the high-resolution computed tomography

We report a case of a 52-year-old female with spontaneous disappearance of focal ground-glass opacity (GGO) detected on high-resolution computed tomography (HRCT). She initially was found to have a focal GGO lesion on follow-up computed tomography five years after left lower lobectomy for primary lung adenocarcinoma. Two months later, this lesion spontaneously disappeared in spite of the suspicion of subsequent lung cancer. A GGO appearance on HRCT can be found in a variety of diseases with partial air-space filling or interstitial thickening. Lung cancer, especially bronchioloalveolar carcinoma, is also included in the differential diagnosis for GGO lesions. However, there is little definite evidence about the management of lesions showing a GGO appearance. When we detect a GGO lesion, initial monitoring for several months may be useful for excluding the presence of lung neoplasms.