A Manganese Catalyst for Highly Reactive Yet Chemoselective Intramolecular C(sp3)—H Amination

A manganese catalyst is reported that aminates C–H bonds via a mechanism that lies between that of reactive noble metals (concerted) and chemoselective base metals (stepwise). Rather than exhibiting intermediate reactivity and selectivity, [Mn(tBuPc)] is an outlier, and aminates all C(sp3)–H bonds, including 1°, while remaining tolerant of oxidizable π-functionality.