Review of local soft tissue recurrence of breast cancer irradiated with and without actinomycin-D. [Gamma Radiation]

Between 1962 and 1973, regionally recurrent breast cancer was treated in 156 patients by irradiation alone or irradiation with concurrent actinomycin-D. Thirty-two patients were entered into a randomized trial, and 124 patients were retrospectively reviewed. Local control with irradiation alone was achieved in 48 of 80 patients (60 percent) and in 60 of 76 patients (79 percent) treated with irradiation and actinomycin-D (p less than .05). Results were remarkably similar in the randomized and retrospective series.