Advances in Studies on Chemistry, Pharmacological Effect, and Pharmacokinetics of Eurycoma longifolia

Eurycoma longifolia, also known as Tongkat Ali in Malaysia, as one of traditional herbal medicines, is used for centuries in South-East Asia. With the discovery of anticancer and anti-HIV properties, this herbal medicine has attracted great attention recently. In this review, the following information on E. longifolia, including chemistry, bioactivities, pharmacokinetics, clinical studies, and side effects and safety, was introduced. Our results, to a certain extent, will provide scientific base for commercial utilization and clearance of the Tongkat Ali products with regard to consumers' safety.