Triaryl (Z)-olefins suitable for radiolabeling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumors
2011
Abstract A group of ( Z )-1,2-diphenyl-1-[4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]but-1-enes were synthesized using methodologies that will allow incorporation of a [ 124 I]iodine substituent at the para -position of either the C-1 phenyl ring or the C-2 phenyl ring, or a [ 18 F]OCH 2 CH 2 F substituent at the para -position of the C-2 phenyl ring. These [ 124 I] and [ 18 F] radiotracers are designed as potential radiopharmaceuticals to image estrogen positive breast tumors using positron emission tomography (PET).
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