The follow-up observation of 93 overweight or obese patients with type 2 diabetes treated by liraglutide

Objective To observe the clinical effects,adverse effects and compliance of liraglutide for overweight or obese patients with type 2 diabetes mellitus (T2DM).Methods 93 overweight or obese patients with T2DM treated by subcutaneous injection of liraglutide 0.6 mg per day and original treatment.The dosage of liraglutide was increased to 1.2 or 1.8 mg per day gradually.The effects of liraglutide on weight,blood glucose,original treatments were followed up,adverse effects and drug withdrawal were recorded in the first,fourth,twelfth and fifty-fourth weeks.Results After the treatment of one week,32.2％ (22/90)of the patients lost weight.Eight patients lost weight from (86.50 ± 11.66) kg to (83.13 ± 10.88) kg (t =3.32,P ＜0.05)after 54 weeks of the treatment.The body weights of 43 patients after 12 weeks of the treatment decreased significantly compared with baseline(P ＜ 0.01).After 3 days of the injection of liraglutide,the fasting and postprandial blood glucose decreased obviously (t =4.30,6.90 respectively,all P ＜ 0.01),and kept decreasing to the twelfth week(t =4.58,6.71 respectively,all P ＜0.01).83.3％ (20/24) of the 24 patients who combined with insulin discontinued or decreased the dosage of insulin after 12 weeks and only two of them happened with slight hypoglycemia reaction.The main adverse effects were anorexia,nausea,vomiting,diarrhea and anorexia was most common.All of these were in remission in 4 weeks and nausea disappeared in 5 days as well as diarrhea.23.7％ (22/93) of the patients stopped liraglutide mostly because of the cost,it made up about 68.2％ (15/22).Conclusions Liraglutide can lose weight and reduce blood glucose effectively and rapidly.The main adverse effect is gastrointestinal reaction and is transient.The incidence rate of hypoglycemia is very low with liraglutide. Key words: Liraglutide ;  Type 2 diabetes mellitus ;  Overweight ;  Obesity