Use of sequential teboroxime imaging for the detection of coronary artery occlusion and reperfusion in ischemic and infarcted myocardium

Abstract Nine Yorkshire pigs underwent coronary artery occlusion followed by 2 hours of reperfusion. In five pigs (group A) the occlusion time was 15 minutes and in four pigs (group B) the occlusion time was 1 hour. Teboroxime was administered and images were acquired at baseline, and following occlusion and reperfusion. Infarct size was determined by triphenyl tetrazolium staining. Normalized regional myocardial blood flow, as determined by radio-labeled microspheres, was 0.26 ± 0.09 following occlusion and 0.83 ± 0.07 following reperfusion ( p p p