PD23-01 SMALL-WORLD BRAIN NETWORK TOPOLOGY IN WOMEN WITH AND WITHOUT OVERACTIVE BLADDER

INTRODUCTION AND OBJECTIVES:The recently emerging field of network neuroscience provides new opportunities to investigate network topology of the whole brain organization; however, the brain network topology in micturition states has not been measured. Accumulating evidence suggests that the human brain can be characterized as a small-world network which is optimally organized for efficient information integration. Previous neuroimaging studies have shown that overactive bladder (OAB) is associated with functional abnormalities in specific brain regions; however, the extent to which brain network topology is altered by OAB remains unknown. The aim of this study is to use functional magnetic resonance imaging (fMRI) to explore brain small-world network changes during bladder filling in women with OAB as well as in healthy controls. To our knowledge, this is the first study to apply the concepts of small-world brain network topology to micturition.METHODS:Eleven women with OAB and 11 healthy controls were s...