AMPATH Oncology: Baseline HPV detection in Kenyan women enrolled in a longitudinal study of modifiable factors predicting cervical dysplasia.

5533Background: Cervical cancer is caused by oncogenic HPV types. Kenyan women, HIV-infected or uninfected were studied to define modifiable factors predicting incidence and persistence of HPV and cervical dysplasia. Methods: From 9/21/2015 to 10/4/2016, 223 women ages 18 to 45 years old with normal VIA at enrollment were enrolled in a longitudinal study in Kenya. Cervical swabs, behavioral data, and other data were collected. HPV typing was performed on clinician-obtained cervical swabs using the Roche Linear Array. Results: Analysis of 219 evaluable participants was done, including 115 HIV-infected (median age 36 years) and 104 HIV-uninfected women (median age 33 years) (p = .0009). Among HIV-infected women, 86.8% were receiving anti-retroviral therapy (ART); median duration between HIV diagnosis and enrollment was 7.2 years (IQR 4.1-10.3); median CD4 count was 471 (IQR 310-612). There was a significant difference in number of lifetime sex partners between HIV-infected (median 4, IQR 3-8) and HIV-uninfe...