Progress in research on herpes simplex virus type II vaccine.

Herpes simplex virus typeⅡ(HSV-2)is a pathogen mainly causing human genital herpes,a widespread sexually transmitted disease in the world especially in underdeveloped countries and regions.HSV-2 infection not only seriously threats human health,but also causes great economic loss.Numerous studies on development of HSV-2 vaccines,including inactivated vaccine,live attenuated vaccine,recombinant subunit vaccine,peptide vaccine and DNA vaccine,have been taken for many years.Although progresses have been made,there is yet no licensed HSV-2 vaccine in the world so far.In this paper,the progresses in development of HSV-2 vaccine in recent years are reviewed.