Analysis and evaluation of menopause symptoms and mental status of anxiety and depression in patients with premature ovarian insufficiency

Objective To explore and analyze the menopause symptoms and mental state of anxiety and depression in patients with premature ovarian insufficiency (POI). Methods We collected patients from Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University from January 2016 to May 2018, including 63 POI patients (POI group), 60 healthy patients aged 35-40 years as normal group (control group) and 71 patients aged 45-55 years with menopausal syndrome (MPS) as the experimental control group (MPS group) at the same time. We used Kupperman Menopausal Index (KMI), Anxiety Self Rating Scale (SAS) and Depression Self Rating Scale (SDS) for quantitative assessment. Results 1) A total of 194 cases were enrolled and the age of POI group, control group and MPS group was (37.1±3.1) years, (36.3±4.2) years and (46.3±5.9) years, respectively. 2) The smoking rate of POI group was higher than that of control group and MPS group (P=0.041, P=0.049). 3) There were 23 cases (36.51%) of POI group, 3 cases of control group (5.00%) and 50 cases of MPS group (70.42%) with KMI>6. There were significant differences among the three groups (P 49, the difference was statistically significant among the three groups (P 49 was significantly higher than that of MPS group (P=0.035) and normal group (P 52. The difference was statistically significant (P 52 in POI group was significantly higher than that in MPS group (P=0.048) and normal group (P<0.000 1). 6) The number of patients with the mild, moderate and severe SAS grade was 19 (63.33%), 9 (30.00%) and 2 (6.67%) in POI group, and 12 (57.14%), 8 (38.10%) and 1 (4.76%) in MPS group. There was no statistical difference among different SAS degrees. 7) The number of patients with the mild, moderate and severe SDS grade was 18 (62.07%), 8 (27.59%) and 3 (10.34%) in POI group, and 11 (55.00%), 7 (35.00%) and 2 (10.00%) in MPS group. There was no statistical difference among different SDS degrees. Conclusion POI patients have obvious anxiety and depression tendency. In addition to paying attention to ovarian fertility preservation of these patients, we should pay more attention to the evaluation of these women’s mental health problems and improve their life quality and psychosocial adaptability. Key words: Premature ovarian insufficiency; Perimenopausal syndrome; Anxiety; Depression