Endothelin-1 Activates the Notch Signaling Pathway and Promotes Tumorigenesis in Giant Cell Tumor of the Spine

Study Design.Experimental study.Objective.To examine the role of endothelin-1 (ET-1) and the Notch signaling pathway in giant cell tumor (GCT) of the spine.Summary of Background Data.Previously published studies have shown that the Notch signaling pathway has a role in tumor invasion and that ET-1 i