Interferon-b Inhibits Liver Metastases from Murine Colon 26 Carcinoma and its Highly Metastatic Variant

Purpose The antitumor effects of Interferon-β (IFN-β) are due to its direct inhibition of cell proliferation, immunostimulatory activity, and the inhibition of angiogenesis. We investigated the mechanism of the effects of IFN-β on a murine colon 26 cell line (CT 26) and its highly metastatic variant (L5).