Anti-inflammatory Activity of Chrysanthemum indicum L. Extract in Lipopolysaccharide-treated Rats

This study for developing a new anti-inflammatory medicine was sought by investigating the antiinflammatory properties of C. indicum L. extract. Rats were treated with either saline (control) or C. indicum L. extract and then injected with LPS. We found that the plasma concentration of IL-1 IL-6, TNF-and IL-10 peaked at 5h after LPS injection, and the plasma concentration of IL-6 and TNF- showed a tendency to decrease, and IL-10 concentration showed a tendency to increase with increasing levels of C. indicum L. extract. In the liver concentration of cytokines at 5 h post LPS injection, IL-1 and IL-6 decreased with increasing concentration of C. indicum L. extract, however TNF- and IL-10 did not differ significantly the treatment groups.