Formulation and In-vitro Evaluation of Bio-Adhesive Gastroretentive System Using Nifidipine.

The gastrointestinal (GI) tract has advanced consistently in terms of technology and diversity, encompassing a variety of systems and devices such as floating systems, raft systems, expanding systems, swelling systems, bio-adhesive systems and low-density systems. Gastric retention will provide advantages such as the delivery of drugs with narrow absorption windows in the small intestinal region. Also, longer residence time in the stomach could be advantageous for local action in the upper part of the small intestine, for example treatment of peptic ulcer disease. Furthermore, improved bioavailability is expected for drugs that are absorbed readily upon release in the GI tract. Bio-adhesive system layer will adhere on gastric mucus which can provide significant of gastro-retentive system. Nifedipine- (anti-hypertensive drug) which is primarily absorbed from stomach and required more than three times a day but by using bio-adhesive layer it can be retain on stomach for more absorption and will reduce the frequency of dosing. The aim of study was to formulate and optimize the bio-adhesive gastro-retentive system of anti-hypertensive drug Nifidipine. Bioadhesive layer will adhere to gastro mucous which can provide the significance of gastro-retentive system.