A human factor VIIa concentrate and its effects in the hemophilic A dog.

Abstract Properties of a new concentrate of FVII/FVIIa, obtained by adsorption onto an inorganic adsorbent followed by a chromatographic step onto Q-Sepharose using a by-product of routine fractionation as starting material,are described.This fraction contains only small amounts of the other components of the prothrombin complex but it is enriched in Proteins C and S.This preparation is essentially free of FVIIICag. It has been submitted to animal experiments including these carried out on normal and hemophilic A dogs.A normalization of the buccal bleeding time was seen after injection of a minimal dose of 4 uFVIIa/kg.No adverse reaction was observed at any dose employed.This concentrate might thus be indicated for the treatment of Haemophilia. A patients with inhibitors. Its viral inactivation has been achieved.