Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging
2011
The development of multifunctional nanomaterials is currently a topic of interest in the field of nanotechnology.
Integrated systems that incorporate therapeutics, molecular targeting, and diagnostic imaging capabilities are considered
to be the next generation of multifunctional nanomedicine. In this work, we present the first example of using Au
nanorods simultaneously serving not only as photodynamic and photothermal agents to destroy A549 malignant cells but
also as optical contrast agents simultaneously to monitor cellular image. Au nanorods were successfully conjugated with
hydrophilic photosensitizer, indocyanine green (ICG), to achieve photodynamic therapy (PDT) and hyperthermia. With
the combination of PDT and hyperthermia proved to be efficiently killing cancer cells as compared to PDT or
hyperthermia treatment alone and enhanced the effectiveness of photodestruction. Moreover, Au nanorods conjugated
with ICG displayed high chemical stability and simultaneously acted as a promising cellular image probe. As a result, the
preparation of Au nanorods conjugated with photosensitizers as well as their use in biomedical applications is valuable
developments in multifunctional nanomaterials.
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