Multidimensional chemical control of CRISPR–Cas9

Basudeb Maji,Christopher L. Moore,Bernd Zetsche,Sara E. Volz,Feng Zhang,Matthew D. Shoulders,Amit Choudhary

Multidimensional chemical control of CRISPR–Cas9

2017

Basudeb Maji
Christopher L. Moore
Bernd Zetsche
Sara E. Volz
Feng Zhang
Matthew D. Shoulders
Amit Choudhary

Small-molecule control of transcriptional activation and genome editing was achieved by tethering inducible protein degron domains to an engineered CRISPR–Cas9 system.

Keywords:

CRISPR
Degron
Molecular biology
Transcription (biology)
Biology
Chemical genetics
Synthetic biology
Genome editing
Bioinformatics
Tethering
Transcription factor

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