Biological diagnosis of monoclonal immunoglobulins

: The demonstration and characterization of monoclonal immunoglobulins in biological fluids are usually performed using electrophoresis coupled to antigen-antibody reactions. This paper briefly discusses the most commonly used techniques. Small, often multiple serum monoclonal immunoglobulins, mostly unrelated to malignant proliferations, are frequent when using recent high resolution methods. Their pathological significance should take into account a number of physiological, clinical and biological data.