The Fetal/Placental Weight Ratio is Associated with the Incidence of Atopic Dermatitis in Female Infants during the First 14 months: The Hamamatsu Birth Cohort for Mothers and Children (HBC Study)

Abstract Aim The present study investigated the sex-specific relationship between the fetal/placental weight ratio and incidence of atopic dermatitis in infants during the first 14 months of life. Methods Study participants were 922 infants (462 females and 460 males) from singleton pregnancies enrolled in the Hamamatsu Birth Cohort for Mothers and Children (HBC Study) after the exclusion of 298 subjects with missing data on atopic dermatitis. The enrollment of infants with atopic dermatitis was based on a positive response from parents regarding whether a physician had ever diagnosed their child with atopic dermatitis by 14 months of age. The two-sample Wilcoxon rank-sum test or chi-squared test was adopted for descriptive analyses where appropriate. Unadjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the infantile incidence of atopic dermatitis were compared using logistic regression analyses. Results Maternal and perinatal factors did not correlate with the incidence of infantile atopic dermatitis. The fetal/placental weight ratio, but not birth or placental weight, correlated with the incidence of atopic dermatitis in female, but not male, infants. A correlation was still observed after adjustments for maternal allergies, gestational age at birth, maternal smoking during pregnancy, and household income at birth (OR: 1.57, 95% CI: 1.05-2.33). Conclusions We speculated that the intrauterine fetal environment, represented by a relatively small placenta, programs a predisposition in female infants only to atopic dermatitis during the first 14 months of life.