The clinical effect of butylphthalide in the treatment of acute cerebral infarction

Objective To investigate the clinical value of butylphthalide in patients with acute cerebral infarction. Methods 120 patients with acute cerebral infarction were randomly divided into study group and control group according to the method of random number table, 60 cases in each group.The study group used butylphthalide on the basis of routine treatment, while the control group only received routine treatment.Main outcome measures included the National Institutes of Health Stroke Scale (NIHSS) table, activities of daily living Barthel index, blood viscosity, clinical curative effect and health related quality of life (HRQL) score. Results There was no significant difference in NIHSS score, Barthel score, blood viscosity and HRQL between the two groups on admission (P>0.05). When compared with the control group after 3 months, NIHSS score of the study group decreased significantly[(948±3.84)points vs.(14.38±3.29)points, t=5.395, P=0.000], Barthel score increased significantly[(84.44±10.59)points vs.(75.89±8.39)points, t=3.854, P=0.015]; blood viscosity decreased significantly[(5.09±0.64)mPa.s vs.(648±0.71)mPa.s, t=7.493, P=0.000]; HRQL scores increased significantly [(80.47±15.39)points vs.(69.58±14.39)points, t=4.395, P=0.002]; clinical curative effect in the study group was significantly higher than control group (χ2=6.122, P=0.013). Conclusion Butylphthalide is helpful to improve the prognosis and quality of life in patients with acute cerebral infarction. Key words: Acute cerebral infarction; Butylphthalide; Clinical curative effect