A CLINICALAND PHARMACOKINETICSTUDYOF INDOMETHACININSTANDARD AND SLOW RELEASE FORMULATIONS

the first 2 week treatment period each patientreceived the two alternative active treatmentschedules for 2 weeks each in random order.ParacetamolorDistalgesictabletswereissuedtoeachpatient for escape analgesia. At the end of thewashoutperiod, andat theendofeach2weektreat-ment period, clinical assessments were performedbetween 11.00hand12.00hbythesameobserveroneach occasion (K.R.H.A.)The clinical assessmentsincluded (Baberetal., 1980):