Effect of Hypoglycemic Anti-deafness Prescription on Blood Glucose in Animal Model of Diabetic Deafness

Objective: To investigate the effect of lowering sugar and preventing deafness prescription on blood glucose in animal models of diabetic deafness. Methods: Fifty Wistar rats were randomly selected from 40 rats to establish the animal model of experimental diabetic deafness by intraperitoneal injection of 55mg/kg streptozotocin (STZ). The remaining 10 rats were normal control group (group A), and after modeling, they were randomly divided into model control group (group B), low-concentration group (group C) and high-concentration group (group D) of the suspension of the formula for lowering sugar and preventing deafness, metformin control group (group E). Group A was fed the normal diet and given the same dose of normal saline as the other groups, group B was given the same dose of normal saline as the other groups, and the metformin groups in groups C, D and E were given 3.3g/kg.d, 30g/kg.d and 0.3mg/kg.d of hypoglycemic and anti-hearing suspension and metformin aqueous solution, respectively. The administration period was 30 days. Results: Compared with normal control group, fasting blood glucose in model control group was increased, the difference was statistically significant (P 0.05), and the indexes of each dose group of Jiangtang Fang Deaf Formula were not statistically significant compared with the metformin control group (P BBB>05). Conclusion: Jiangtang Fang Deafness Decoction can improve the blood glucose of diabetic deafness animal models.