Efficacy of methanol extract of Zingiber officinale rhizome against acute pneumonia caused by Pseudomonas aeruginosa

Pseudomonas aeruginosa has become one of the major threats to public health as it causes serious diseases like pneumonia and the condition becomes sever if the disease is caused by drug-resistant strain. Thus, in the present study, the antibacterial activity of Zingiber officinale against P. aeruginosa causing a lung infection in Swiss albino mice was evaluated. Disease analysis includes bacteremia, x-rays based observation of patches formation in lungs, and destruction of lung tissue. Bacterial load showed a significant decline in the herbal treated group up to 1.13 ± 0.2 Log10 CFU/ml at the 7th day as compared to the untreated group with the bacterial burden 3.0 ± 0.12 Log10 CFU/ml. The histopathology reveals more distorted alveoli in an infected group with an accumulation of immune cells while in the treated group improved lung histology was seen. The findings stated that Z. officinale is effective may provide a suitable lead for future development and possible clinical utility as inhibitors of lung infection caused by P. aeruginosa.