Effects of reperfusion method and time on myocardium survival index in acute myocardial infarction

Objective:To explore the relationship between myocardium survival index and time interval from onset to treatment in patients with acute myocardial infarction (AMI) treated with coronary artery stenting or thrombolysis.Methods:The 178 AMI patients were randomily divided into coronary stenting group (89 patients) or thrombolysis group (89 patients).Patients of two groups also were divided into following 3 sub-groups defined by time interval from onset to treatment:lower time interval (3 h), middle time interval (3 h to 5h), and upper time interval (5 h).Paired scintigraphic examinations were performed to obtain myocardial survival index.Results:In the thrombolysis group,the myocardium survival index [median (25th;75th) percentile] was 0.45 (0.16; 0.83) in the lower time interval,0.29 (0.17; 0.48) in the middle time interval,and 0.20 (0.04; 0.46) in the upper time interval (P0.05).In the stenting group, the survival index was 0.56 (0.49; 0.75) in the lower, 0.57 (0.36; 0.73) in the middle, and 0.57 (0.32; 0.75) in the upper interval (P=0.59).The myocardium survival index of middle,upper time interval in AMI patients treated with stenting was better than those of thrombolysis (P0.001).Conclusion:The therapeutic effects of stent implanted in 12 h from onset to treatment are better than those of thrombolysis..