COMMON MECHANISMS IN THE PATHOGENESIS OF METABOLIC SYNDROME, ATHEROSCLEROSIS AND BREAST CARCINOMA AND THE POSSIBILITIES OF USING OMEGA-3 POLYUNSATURATED ACIDS IN THEIR PREVENTION AND THERAPY

Breast cancer is the most common cancer disease among women in economically developed countries. The exact cause of the disease is not fully understood, but a variety of risk factors applies here. Consequently, the prevention has an important role in the reduction of incidence of breast carcinoma. Population of Central and Western Europe consume food with increased content of omega-6 polyunsaturated fatty acids at the expense of omega-3 polyunsaturated fatty acids. Consumption of high-fat diet rich in saturated fatty acids is associated with changes in the proportions of bacterial genera and species of intestinal microbiota. In this way there is development of dysbiosis. The mutual disproportions between the fatty acids, as well as dysbiosis, are risk factors, but also cause of the development of many chronic diseases, too. Keywords:  Polyunsaturated fatty acids, endotoxemia, microbiome, breast cancer, prevention