Comparison of cgmanalysis, a free, open-source continuous glucose monitoring (CGM) data management and analysis software to commercially available CGM platforms: Data standardization for diabetes technology research.

BACKGROUND Cgmanalysis is open-source software based on the R programming language for data management and descriptive analysis of data from continuous glucose monitors (CGM). We sought to validate the summary measures calculated by cgmanalysis against the results from proprietary software associated with 4 CGM commercially available models. METHODS Two weeks of data from 188 patients with type 1 diabetes using commercially available CGMs. Freestyle Libre Gen 1 (n = 53), Medtronic Guardian 3 (n = 52), Dexcom G6 reported by Dexcom Clarity (n = 48) and Dexcom G6 reported by Tandem (n = 35) were analyzed using proprietary software and cgmanalysis. Agreement was assessed using scatter plots, Bland-Altman plots, and equivalence tests. RESULTS Good agreement was obtained for all glycemic summary measures for all CGMs assessed. None of the differences between the cgmanalysis package and the manufacturers' software were outside the prespecified bounds of equivalence. CONCLUSIONS Cgmanalysis is a validated open-source software to analyze commercially available CGM data and can be used to standardize diabetes technology research. The cgmanalysis package is available on CRAN (https://cran.r-project.org/web/packages/cgmanalysis/index.html).