Characteristics of and factors influencing cognitive impairment in adolescent patients with first-episode depression

ABSTRACTThis study aims to explore the characteristics and risk factors of cognitive impairment in adolescent patients with first-episode depression. In total, 128 adolescents with first-episode depression were selected (patient group). Clinical factors, including gender, educational level, suicide risk, sleep status based on the Pittsburg Sleep Quality Index scale (PSQI), and disease duration based on Hamilton Rating Scale for Depression (HRSD), were assessed to identify risk factors. The MATRICS Consensus Cognitive Battery (MCCB) was used to assess 50 health subjects (control group). Data were statistically analyzed using the t test, χ2 test, Pearson’s correlation analysis, and stepwise multiple regression analysis in SPSS 22.0. The total MCCB score in the control group was higher than that in the patient group (P   0.05). Cognitive functional impairment in adolescent patients with first-e...