Karotid Arter Stentleme Sonrası Gelişen Stent-içi Restenozun Yeni Bir Öngördürücüsü: CRP/Albumin Oranı

ABSTRACT Objective:  The present study aimed to assess the predictive value of preprocedural C-reactive protein/albumin ratio (CAR) for in-stent restenosis (ISR) after carotid artery stenting (CAS). Materials and Method:  In this retrospective study, 206 patients who underwent successful CAS procedure in a tertiary heart centre were included. For each patient, both C-reactive protein (CRP) and serum albumin were determined before the index procedure. The CAR was calculated by dividing serum CRP by serum albumin level. The main end-point of the study was ISR during long-term follow-up. Results:  ISR developed in 34 (16.5%) out of 206 patients after a mean follow-up of 24.2 ± 1.5 months. The CAR was significantly elevated in patients with ISR compared to those who were not (0.99 [1.3] vs. 0.15 [0.2], p 0.53 with a sensitivity of 100 % and a specificity of 97.1 %  [area under curve (AUC) 0.98, p 0.53 olmasi, SIR ‘u  %100 duyarlilik ve %97.1 ozgulluk ile ongordurmekteydi  (AUC) 0.98, p < 0.01). Sonuc:  Calismamizin sonuclari gostermistir ki, inflamatuar bazli yeni bir belirtec olan CAO KAS islemi yapilan hastalarin takiplerinde gelisen SIR ‘un guclu ve bagimsiz bir ongordurucusudur. Hizli ve kolayca bakilabilen bu parametre, KAS islemi yapilan hastalarda SIR gelisimini degerlendirmek icin kullanilabilir.  Anahtar kelimeler:  CAO, stent ici restenoz, karotis arter stentleme, inflamasyon