The Tyr978X BRCA1 Mutation in Non-Ashkenazi Jews: Occurrence in High-Risk Families, General Population and Unselected Ovarian Cancer Patients

Ronit Shiri-Sverdlov,Ruth Gershoni Baruch,Galit Ichezkel-Hirsch,Walter H. Gotlieb,Revital Bruchim Bar-Sade,Angela Chetrit,Shulamith Rizel,Baruch Modan,Eitan Friedman

The Tyr978X BRCA1 Mutation in Non-Ashkenazi Jews: Occurrence in High-Risk Families, General Population and Unselected Ovarian Cancer Patients

2001

Ronit Shiri-Sverdlov
Ruth Gershoni Baruch
Galit Ichezkel-Hirsch
Walter H. Gotlieb
Revital Bruchim Bar-Sade
Angela Chetrit
Shulamith Rizel
Baruch Modan
Eitan Friedman

Background: In Jewish individuals of Ashkenazi (East European) decent, three predominant mutations, 185 delAG and 5382insC (BRCA1) and 6174delT (BRCA2)&l

Keywords:

Ovarian cancer
Gynecology
Founder mutation
Population
Breast cancer
Mutation
Medicine
Genetics
brca1 gene
Judaism
high risk families
ashkenazi jews

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