The neuroanatomy of post-polio fatigue.

Fatigue is the most commonly reported, most debilitating and most poorly understood Post-Polio Sequelae (PPS). Postmortem studies of fifty years ago documented frequent and severe poliovirus-induced lesions within the reticular activating system (RAS). Recently, neuropsychological testing has documented marked attention deficits in polio survivors reporting severe fatigue. However, neither of these findings has been related to the pathophysiology of postpolio fatigue. Magnetic resonance imaging of the brain was