Germinoma pineal como causa de panhipopituitarismo: reporte de un caso

Introduction: Intracranial germ cell tumors are rare neoplasms primarily affecting the pediatric population. The clinical presentation varies by location and size. Lesions in the pineal region often cause obstructive hydrocephalus, while lesions in the suprasellar region typically present with hypothalamic-pituitary axis dysfunction. A pineal germ cell tumor presenting with endocrine disturbances is a extremely rare entity. One case of a sixteen-year-old male with panhypopituitarism secondary to a pineal germinoma is reported. Material and methods: This patient was referred to the emergency department after his routine laboratory values showed hypernatremia. He presented with increased thirst, polyuria, and fatigue of one-year duration. Clinical and laboratory evaluation revealed diabetes insipidus, panhypopituitarism, and bitemporal hemianopsia. He received hormone replacement therapy. Three months later, a follow-up magnetic resonance imaging revealed a mass at the pineal region diagnosed as germinoma. Conclusion: After treatment with chemotherapy and radiation, he achieved complete resolution of the lesion. However, there was no marked clinical improvement and he continued to require hormone replacement therapy.