Evaluation of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) blood serum levels in women at high risk for preeclampsia.

PROBLEM The aim of this study was to evaluate the sCEACAM1 concentrations in serum from patients in the first trimester who have a high risk for developing PE during pregnancy. METHOD OF THE STUDY CEACAM1 levels were determined with ELISA. The patients (n=109) were divided into 2 groups: patients who have a high risk of developing PE early-onset and a control group. Patients who have a high risk of developing PE was then divided into 2 subgroups depending on PE development in third trimester of pregnancy: PE in third trimester versus no PE in third trimester. RESULTS sCEACAM1 concentrations in patients who were screened as having a high risk for developing PE were significant higher than in healthy pregnant women in the first trimester (p=0.03). The highest sCEACAM1 concentration were found in the high risk group with PE developement compared to the control group (p=0.004). CONCLUSION Elevated sCEACAM1 blood serum levels in women with PE suggest that there is immune dysregulation in early pregnancy, which may be helpful in PE prediction and therapy.