Bone Turnover in Cortical and Trabecular Bone in Normal Women and in Women with Osteoporosis

This study is based on the assumption that if bone turnover, shown by the uptake of 99m Tc-MDP, indicates a high rate of bone loss in patients with osteoporosis, it could potentially predict bone loss in patients at risk before significant bone loss has occurred. Methods: Quantitative bone SPECT (QBS) using 99m Tc-MDP, expressed as the %ID/cc×10 -3 , was performed in 71 women who had osteoporosis in the lumbar vertebrae, the femoral neck or both, and in 54 age-matched normal female controls. Of the women with osteoporosis, 42 had postmenopausal osteoporosis and 29 had primary hyperparathyroidism (HPT) and osteoporosis