Effect of Maiqi Yifei Mixture on the Balance of Th1/Th2 in Mice with Asthma and Its Safety Study

OBJECTIVE:To investigate the influence of Maiqi yifei mixture on the balance of Th1/Th2 and its safety by observing the changes of T lymphocytes in peripheral blood of mice with respiratory allergy.METHODS:The asthma mice model was induced by 1% OVA,and model mice were randomized into normal groups,asthma model group and Maiqi yifei mixture group.The expressions of IL-4 and IFN-γ in peripheral blood cells were determined by flow cytometer.Mice were given maximal dose of drugs via i.g.gtt.Control group received same quantity of normal saline.The change of symptoms and body weight of mice were observed.RESULTS:Model group showed significant non-specific inflammation reaction symptoms,while Maiqi yifei mixture group hadn't significant inflammation reaction symptoms.The expression of Th1 in mice of Maiqi yifei mixture group was higher than in asthma model group(P0.01).The IL-4 level in mice of model group was higher than in normal group(P0.01).After giving maximal dosage,the symptom and body weight of mice had no significant difference(P0.05).CONCLUSION:Maiqi yifei mixture can prevent respiratory allergy of mice in the stimulated period.One of its mechanisms is regulating the balance of Th1/Th2.