ORAL MANIFESTATIONS OF CHRONIC GRAFT-VERSUS-HOST DISEASE: REPORT OF 2 CASES

Chronic graft-versus-host disease (GVHD) is a major late complication in patients treated by allogeneic hematopoietic stem cell transplantation. It is defined as a multisystem alloimmune and autoimmunelike disorder characterized by immune dysregulation, immune deficiency, impaired end-organ function, and decreased survival. Chronic GVHD resembles both clinically and histologically, many autoimmune disorders and other immunologic diseases. The oral cavity is the second most commonly involved organ system, behind skin involvement and can present as mucosal erythema, lichenoid lesions, ulcerated mucosa, and leukoplakia lesions that may be considered a potential risk factor for the development of oral cancer. We report the clinical features of 2 cases, occurring in a 41-year-old man and a 60-year-old woman. Both patients had a favorable outcome treated with topical or systemic corticosteroids and, in 1 of the cases, with the cyclosporine adjustment.