The study on significance of detecting the hepatitis B virus large proteins in public health physical examination

Objective It was to explore the application of the hepatitis B virus large proteins( HBVLP) in public health physical examination through clinical testing of HBV-LP in Catering practitioners, students and soldiers of New requisition etc. Methods 709 samples of HBV infection people were collected in public health physical examination and all collected samples were detected. ELISA was used to detect HBV serum markers (HBV-M ) and HBV-LP. Real-time PCR was applied to detect quantity of HBV DNA. Results ( 1 ) The detectable results of HBV-LP and HBV DNA were no statistical significance in 709 samples. ( 2 ) The detectable results of HBV-LP and HBV DNA were also no statistical significance in different models of HBV infection patients. The values of x2 and P were respectively 2. 67,0. 60,0. 00 and 0. 10,0.44,1. 00. S/A of HBV-LP and the copies of HBV-DNA had a positive relationship (r = 0. 959 ,P ＜ 0. 05). Conclusion HBV-LP could reflect the level of hepatitis B virus replication and be used to judge the level of hepatitis B virus replication in people of public health physical examination. HBV-LP may be worth using widely in physical examination. Key words: Hepatitis B;  Viral envilope protein;  Liver function tests