Facile fabrication of reduction-responsive nanocarriers for controlled drug release

An amphiphilic multiblock poly(ether–ester) containing multiple thiols was facilely synthesized by “one-pot” polycondensation of dihydroxyl poly(ethylene glycol), 1,4-butanediol and mercaptosuccinic acid, which could be used to fabricate reduction-responsive core-crosslinked micelles for controlled drug release.