Dual effects of a high-protein diet on DSS-treated mice during colitis resolution phase

A high-protein diet exerts a biphasic effect on dextran sulfate sodium (DSS)-induced colitis by worsening inflammation during the induction-resolution phase, but also by helping colonic crypt repair after acute inflammation likely through modulation of colonic epithelial proliferation, differentiation, and expression of intestinal barrier proteins. This study points out the potential impact of the dietary protein amount during the colitis course and raises the possibility of a causal link between colonic epithelial repair and survival in our irritable bowel diseases (IBD) model.